Prognostic Markers for Immunochemotherapy Using Tegafur-Uracil (UFT) and Protein-Bound Polysaccharide K (PSK)

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  • Yoshinaga Keiji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Saeki Hiroshi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Oki Eiji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Morita Masaru
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Ikeda Tetsuo
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Sugimachi Keishi
    Department of Surgery, Kyushu University Beppu Hospital
  • Yamashita Yo-ichi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Ikegami Toru
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Uchiyama Hideaki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Yoshizumi Tomoharu
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Soejima Yuji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Kawanaka Hirofumi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • Mimori Koshi
    Department of Surgery, Kyushu University Beppu Hospital
  • Watanabe Masayuki
    Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University
  • Maehara Yoshihiko
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 胃癌・大腸癌症例に対するクレスチン(PSK)療法のレスポンダー探索

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Abstract

Aim/Background : We previously reported that PSK-induced lymphocyte blastogenesis reaction (PSK-stimulation index ; PSK-SI) may be a prognostic marker for immunochemotherapy using PSK in gastrointestinal cancer patients. In this study we evaluated the usefulness of PSK-SI as a prognostic marker for PSK therapy at higher and lower serum immunosuppressive acidic protein (IAP) levels. Patients and Methods : 98 gastric and 135 colorectal cancer patients were analyzed. PSK-SI and serum IAP levels were measured preoperatively. After operation, patients received UFT and PSK for two years. Results : There were no differences between patients with higher and those with lower PSK-SI with respect to the clinicopathological factors. In patients with higher serum IAP levels (≥ 500μg/ml), recurrence-free survival (RFS) and overall survival (OS) were apparently more favorable in the higher PSK-SI group (gastric cancer ; ≥ 1.75, colorectal cancer ; ≥ 2.1) than in lower PSK-SI group, although the differences were not significant. Conclusion : Serum IAP levels and PSK-SI may be useful markers for prediction of response to immunochemotherapy using PSK, although further studies are necessary.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 104 (12), 549-558, 2013-12-25

    Fukuoka Medical Association

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