Preferential Expression of OVOL1 in Inner Root Sheath of Hair, Sebaceous Gland, Eccrine Duct and their Neoplasms in Human Skin
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- Mitoma Chikage
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Nakahara Takeshi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Uchi Hiroshi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Ito Takamichi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Inatomi Yusuke
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Ide Takatoshi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Jinnai Shunichi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Jinnai Naomi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Iwasaki Nahoko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Sakamoto Keiko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Kimura Nanae
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Maeda Ayami
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Kuma Yuki
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Maehara Eriko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Tsutsumi Midori
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Nakahara Makiko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
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- Hirota Tomomitsu
- Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN
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- Tamari Mayumi
- Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN
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- Furue Masutaka
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
Bibliographic Information
- Other Title
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- OVOL1はヒト皮膚の内毛根鞘,脂腺,汗腺とその腫瘍に発現している
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Abstract
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.
Journal
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- 福岡醫學雜誌
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福岡醫學雜誌 105 (8), 166-173, 2014-08-25
Fukuoka Medical Association
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Details 詳細情報について
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- CRID
- 1390853649694532480
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- NII Article ID
- 120005511933
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- NII Book ID
- AN00215478
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- DOI
- 10.15017/1470735
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- HANDLE
- 2324/1470735
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- NDL BIB ID
- 026014889
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- ISSN
- 0016254X
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- PubMed
- 25509883
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Allowed