Overexpression of p16^〈INK4a〉 in Mastocytosis (Urticarial Pigmentosa)
-
- Tsujita Jun
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Doi Kazuko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Nakahara Makiko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Nakahara Takeshi
- Division of Skin Surface Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Kaku Yumiko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Nishio Kiichiro
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Kan Nagisa
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Sato Yuki
- Department of Dermatology, Graduate School of Medical Sciences Kyushu University
-
- Nagata Shoko
- Department of Dermatology, Graduate School of Medical Sciences Kyushu University
-
- Nakao. Asako
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Yoshida Maiko
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Uchi Hiroshi
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
-
- Furue Masutaka
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University | Division of Skin Surface Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
Bibliographic Information
- Other Title
-
- 肥満細胞症(色素性蕁麻疹)におけるp16^〈INK4a〉の高発現
- Overexpression of p16INK4a in Mastocytosis (Urticarial Pigmentosa)
Search this article
Abstract
The expression of p16^〈INK4a〉 has been reported to induce cell-cycle arrest and cellular senescence. The p16^〈INK4a〉 expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16^〈INK4a〉 and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean±standard deviation)% of tryptase-positive mast cells coexpressed p16^〈INK4a〉. However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16^〈INK4a〉 in all of 4 mastocytosis. The p16^〈INK4a〉 overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
Journal
-
- 福岡醫學雜誌
-
福岡醫學雜誌 107 (1), 12-17, 2016-01-25
Fukuoka Medical Association
- Tweet
Details 詳細情報について
-
- CRID
- 1390853649694753408
-
- NII Article ID
- 120005757947
-
- NII Book ID
- AN00215478
-
- DOI
- 10.15017/1657145
-
- HANDLE
- 2324/1657145
-
- NDL BIB ID
- 027563121
-
- ISSN
- 0016254X
-
- PubMed
- 27333655
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Allowed