ベンゾピレンの末梢神経および脊髄感覚系シナプス伝達に及ぼす作用に関する研究

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  • Effects of Benzo [a] pyrene on Conduction Velocity of the Rat Dorsal Root and Synaptic Transmission in Substantia Gelatinosa (SG) Neurons of the Rat Spinal Dorsal Horn
  • ベンゾピレン ノ マッショウ シンケイ オヨビ セキズイ カンカクケイ シナプス デンタツ ニ オヨボス サヨウ ニ カンスル ケンキュウ

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In the present study, we analyzed the effects of benzo[a]pyrene on conduction velocity (CV) of action potentials (APs) generated by electrical stimuli applied to the dorsal root in acutely isolated rat dorsal root ganglion (DRG) preparations using intracellular recordings. We also measured the effects of benzo [a] pyrene on spontaneous excitatory and inhibitory synaptic responses (sEPSC and sIPSC) and excitatory synaptic responses evoked by dorsal root stimuli in substantia gelatinosa (SG) neurons of the spinal dorsal horn, which receive inputs predominantly from Aδ and C afferent fibers, using patch-clamp recordings. In the present results, benzo [a] pyrene did not affect on resting membrane potentials of Aβ, Aδ and C neurons. In addition, benzo [a] pyrene did not exhibit any effect on conduction velocities of Aδ and C fibers, but that of Aβ fiber was significantly decreased. The amplitude and frequency of both sEPSC and sIPSC in SG neurons of the spinal dorsal horn were not affected. In addition, the synaptic responses elicited by stimulation of Aβ, Aδ and C afferents were not changed by benzo [a] pyrene. From the present results, benzo [a] pyrene causes a change in the conduction velocity of Aβ but not Aδ and C afferent fibers, suggesting that this change causes paresthesia, such as numbness and loss of sensation. However, benzo [a] pyrene does not affect the synaptic transmission in SG of the spinal dorsal horn.

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