油症一斉検診における血液試料中の2,2ʼ,3,4,4ʼ,5ʼ,6- Heptachlorobiphenyl（PCB183）のキラル分析

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  • Enantiomeric Analysis of 2,2ʼ,3,4,4ʼ,5ʼ,6-Heptachlorobiphenyl in the Blood of Examinees Collected during Medical Check-up for Yusho
  • 油症一斉検診における血液試料中の2,2',3,4,4',5',6-Heptachlorobiphenyl(PCB183)のキラル分析
  • ユショウ イッセイ ケンシン ニ オケル ケツエキ シリョウ チュウ ノ 2,2',3,4,4',5',6-Heptachlorobiphenyl(PCB183)ノ キラル ブンセキ

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抄録

Among 209 Polychlorinated biphenyl (PCB) congeners, 19 congeners are known to have enantiomers. In this study, we analyzed 2,2ʼ,3,4,4ʼ,5ʼ,6-Heptachlorobiphenyl (PCB183) in the human blood enantioselectively, and quantified the enantiomer-specific accumulation. The samples were collected during medical check-up for Yusho from 2015 through 2017. The average enantiomeric fraction (EF) of PCB183 in samples were 0.718. This fact indicates that PCB183 (+) has greater bioaccumulation potential than PCB183 (−) in human body. In addition, we analyzed statistical relationships between EFs and diagnostic criteria of Yusho. As the result, it was suggested that the EFs for PCB183 is not related to sex, age, concentration of 2,3,4,7,8-Pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and the gas chromatographic pattern of blood PCBs.

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