Blood Dioxin Concentrations and their Tendencies Examined in 2001-2017 Annual Inspections for Yusho

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  • Hori Tsuguhide
    Fukuoka Institute of Health and Environmental Sciences
  • Yasutake Daisuke
    Fukuoka Institute of Health and Environmental Sciences
  • Hirakawa Hironori
    Fukuoka Institute of Health and Environmental Sciences
  • Todaka Takashi
    Kitakyushu Life Science Center
  • Hirose Yuki
    Kitakyushu Life Science Center
  • Shintani Yoriko
    Fukuoka Institute of Health and Environmental Sciences
  • Kajiwara Junboku
    Fukuoka Institute of Health and Environmental Sciences
  • Katsuki Susumu
    Fukuoka Institute of Health and Environmental Sciences
  • Mitoma Chikage
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital
  • Furue Masutaka
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital

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Other Title
  • 油症認定患者及び未認定者の血液中ダイオキシン類濃度と傾向 （2001〜2017年度）
  • ユショウ ニンテイ カンジャ オヨビ ミニンテイシャ ノ ケツエキ チュウ ダイオキシンルイ ノウド ト ケイコウ(2001~2017ネンド)

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Abstract

We performed congener specific analysis of dioxins using HRGC/HRMS and determined their concentrations in blood samples collected from approx. 1,700 persons during annual Yusho examinations between 2001 and 2017. When concentration of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) was compared in seven Yusho patients undergoing examinations among the seventeen years, the longitudinal concentrations in the respective individuals hardly changed over these years. Mean concentration of 2,3,4,7,8-PeCDF in blood from Yusho patients registered by annual inspections for Yusho was calculated as 110 pg/g, which was 80％ higher than the mean value of 17 pg/g in normal controls, and the rates of persons with blood 2,3,4,7,8-PeCDF concentrations below 50 pg/g in the entire patients occupied approx. 60％. On the other hand, in a subset of Yusho patients registered by the supplemental criteria revised on 2012, it was found that the median values of concentration of 2,3,4,7,8-PeCDF were similar to the those of normal controls.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 110 (2), 61-66, 2019-06-25

    Fukuoka Medical Association

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