油症認定患者及び未認定者の血液中ダイオキシン類濃度と傾向 (2001〜2017年度)

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  • Blood Dioxin Concentrations and their Tendencies Examined in 2001-2017 Annual Inspections for Yusho
  • ユショウ ニンテイ カンジャ オヨビ ミニンテイシャ ノ ケツエキ チュウ ダイオキシンルイ ノウド ト ケイコウ(2001~2017ネンド)

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We performed congener specific analysis of dioxins using HRGC/HRMS and determined their concentrations in blood samples collected from approx. 1,700 persons during annual Yusho examinations between 2001 and 2017. When concentration of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) was compared in seven Yusho patients undergoing examinations among the seventeen years, the longitudinal concentrations in the respective individuals hardly changed over these years. Mean concentration of 2,3,4,7,8-PeCDF in blood from Yusho patients registered by annual inspections for Yusho was calculated as 110 pg/g, which was 80% higher than the mean value of 17 pg/g in normal controls, and the rates of persons with blood 2,3,4,7,8-PeCDF concentrations below 50 pg/g in the entire patients occupied approx. 60%. On the other hand, in a subset of Yusho patients registered by the supplemental criteria revised on 2012, it was found that the median values of concentration of 2,3,4,7,8-PeCDF were similar to the those of normal controls.

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