Studies on Mycoplasma pneumoniae Infections with Special References to the Usefullness of Complement Mediated Mycoplasmacidal Serum Antibodies

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  • Mycoplasma pneumoniae 感染症に関する研究 : 特に血清の補体依存性mycoplasmacidal抗体価の有用性について
  • Mycoplasma pneumoniae カンセンショウ ニカンスルケンキュ

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Pneumonia associated with Mycoplasma pneumoniae (M. pneumoniae) infection is said to occur most commonly among Children of 5 to 15 years of age and is uncommon in infants. The reason for this unusual age distribution as reported is still unknown. In order to clarify this, M. pneumoniae infection was investigated in children of various age groups. The methods employed to detect the infection are the commonly used complement fixation (CF) test for M. pheumoniae and mycoplasmacidal (MC) test which is considered to be more sensitive than the former. The following results were obtained : 1) Complement mediated MC test was superior in its specificity and sensitivity to detect M. pneumoniae infection compared with CF test. 2) Because of its insensitivity, CF test could not detect the M. pneumoniae infection in infants, although positive tests resulted in older children by this method. On the other hand, remarkable positive results were obtained by MC test even in infants. Based on this result, it was concluded that the age distribution mentioned above could be explained not by infectious status but the method employed to determine M. pneumoniae infections. 3) MC antibody belongs mainly to IgM in the initial period of the infection, and thereafter changes to IgG in 2 or 3 weeks. This MC antibody in IgG fraction may be transplacental.

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