The relationship between taste threshold change and serum zinc level in cancer patients treated with anticancer drugs <Original Articles>

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  • 抗がん剤投与後の味覚変化と血清亜鉛値との関連 <原著論文>
  • 抗がん剤投与後の味覚変化と血清亜鉛値との関連
  • コウガンザイ トウヨ ゴ ノ ミカク ヘンカ ト ケッセイ アエンチ ト ノ カンレン

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Abstract

Taste disorder is one of the most frequent side effects of chemotherapy. A relationship between serum zinc level and taste sensitivity has been pointed out in previous reports, but there have only been a few reports showing the effect of serum zinc level on taste sensitivity after anticancer drug administration. The purpose of this study was to examine the serum zinc levels and taste thresholds of cancer patients treated with anticancer drugs and to determine whether they are related. Taste thresholds and levels of serum trace elements (zinc and copper) were measured in 60 cancer patients before administration of anticancer drugs and on the three and six days after administration. There were significant differences in the salt threshold with elapse of time after chemotherapy (p<0.01). There were also significant differences in the serum zinc level with elapse of time after chemotherapy (p<0.01). There was a significant relationship between low salt sensitivity and change in serum zinc value (r = -0.402, p<0.01). Although there was no significant relationship between serum copper value and taste sensitivity, there was a relationship between salt sensitivity and serum zinc value.

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