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気管支喘息に対する温泉療法とα-リノレン酸強化食の効果

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  • Effects of spa therapy combined with dietary supplementation with alpha -linolenic acids on bronchial asthma
  • Effects of spa therapy combined with dietary supplementation with アルファ linolenic acids on bronchial asthma
  • Effects of spa therapy combined with dietary supplementation with α-linolenic acids on bronchial asthma

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Abstract

N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil- rich diet (rich in n-3 fatty acid)were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil- rich diet - rich in a -linolenic acid (alpha-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P<O.05). Peak expiratory flow (PEF) values increased significantly for 2,4, 6 and 8 weeks (P<O.05). The values of ventilatory parameters [forced vital capacity (FVC) , forced expiratory volume in one second (FEV(1)) forced expiratory flow after 25% of expired FVC (FEF(25)), forced expiratory flow after 75% of expired FVC (FEF (75)) • mean expiratory flow during the middle half of the FVC (FEF(25-75)) ] revealed a significant increase after 4 and 8 weeks of the modified diet (P<O.05). The results suggest that spa therapy combined with a perilla seed oil- rich diet are effective in the treatment of asthma in terms of its ability to suppress LTC4 generation by leucocytes, and in inducing an improvement of pulmonary function.

N-3系脂肪酸は喘息に有効であることが報告されている。また喘息に対する温泉療法の有効性も報告されている。今回我々は温泉療法とn-3系脂肪酸を多く含むエゴマ油食の喘息に対する効果を検討した。14名の喘息患者に温泉療法及びα-リノレン酸(n-3系)を多く含むエゴマ油食の摂取を8週間行い,その間の白血球ロイコトリエンC 4(LTC4)の産生能と呼吸機能の変化を検討した。 その結果白血球LTC4の産生能は治療開始2過後より4,8過後と抑制された(P<0.05)Oピークフロー値(PEF)は治療2,4,6,8週後に有意な増加がみられた(P<0.05)。また呼吸機能[努力肺活量(FVC),1秒量(FEV(1)),FEF(25),FEF(75),FEF(25-75)]は治療開始4過,8過後に有意に改善した(P<0.05)。これらの結果より温泉療法とエゴマ油食は白血球LTC4の産生能を抑制することにより,呼吸機能を改善させ,気管支喘息の治療に有効であることが示唆された。

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