Favorable and harmful effects of branched-chain amino acid administration in patients with liver cirrhosis: effects on hepatic encephalopathy and ammonia metabolism

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  • 肝硬変に対する分岐鎖アミノ酸補充療法の効果と弱点：特に肝性脳症，アンモニア代謝への影響に注目して
  • カンコウヘン ニ タイスル ブンキ サ アミノサン ホジュウ リョウホウ ノ コウカ ト ジャクテン : トクニ カンセイ ノウショウ,アンモニア タイシャ エ ノ エイキョウ ニ チュウモク シテ

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Abstract

<p>Liver cirrhosis is associated with impaired liver function due to various metabolic disorders, causing poor prognosis and several complications, such as hepatic encephalopathy. Although a number of studies have reported the favorable effects of branched-chain amino acid (BCAA) administration on hepatic encephalopathy, liver function, and prognosis, several studies have shown that BCAA administration might be associated with the following adverse effects: activated glutamine catabolism to ammonia and drainage of alpha-ketoglutarate from the TCA cycle. This review presents the mechanism and management of the favorable and harmful effects of BCAA administration in patients with liver cirrhosis.</p>

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  • Kanzo

    Kanzo 63 (1), 1-8, 2022-01-01

    The Japan Society of Hepatology

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