A case of spontaneous regression of a rapidly-grown hepatocellular carcinoma

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  • 急速増大後，自然退縮した肝細胞癌の一例
  • キュウソク ゾウダイ ゴ,シゼンタイシュクシタ カン サイボウ ガン ノ イチレイ

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<p>Spontaneous regression of hepatocellular carcinoma (HCC) is rare. Here, we present a rare case of spontaneous regression of a rapidly-grown hepatocellular carcinoma. An 83-year-old man had repeatedly received therapy for recurring HCC for 11 years. The HCC, 1 year ago, had rapidly grown to 68 mm in diameter from 30 mm 3 months prior. The patient refused treatment stating dementia as a reason. After 1 year, the patient returned to our hospital. During this 1 year, the concentration of alpha-fetoprotein (AFP) had remarkably decreased to 2.05 ng/ml from its previous value of 2772 ng/ml. The value of protein induced by the absence of vitamin K or antagonist II (PIVKA-II) had also decreased to 55.11 mAU/ml from 23023 mAU/ml. The contrast-enhanced computed tomography showed that the HCC had shrunk to a diameter of 10 mm. Tumor regression may have been caused by a disturbance in hepatic circulation associated with rapid growth, the location, the formation of a capsule, and the portal vein thrombus.</p>

Journal

  • Kanzo

    Kanzo 63 (2), 51-61, 2022-02-01

    The Japan Society of Hepatology

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