Whole-genome Sequencing-based Lung Cancer Precision Medicine in Japan

DOI Web Site 1 Citations 25 References
  • Kohno Takashi
    Division of Genome Biology, National Cancer Center Research Institute

Bibliographic Information

Other Title
  • 肺がんの全ゲノムシークエンス解析と臨床実装

Search this article

Description

<p>Lung cancer is a cancer for which personalized medicine based on genomic information, including companion diagnostics, such as driver gene mutations, is already available. In addition, after standard treatment is completed, gene panel tests, including liquid biopsies, can be performed under national insurance coverage to seek new treatment methods. However, there is an emerging trend involving the implementation of whole-genome sequencing into cancer care for many intractable cancers, including lung cancer. Given the limited amount of cancer tissue samples available from patients and the fact that the information on genetic alterations required for medical treatment varies greatly among patients, it would be ideal to implement whole-genome sequencing, which has no restrictions on the genes that can be analyzed. However, due to the huge amount of genomic information obtained, the resources and time required to process it, and the need for quality assurance, we are not yet at a stage where this approach can be implemented immediately. Therefore, a national project is set to be launched that will implement whole-genome sequencing of cancer into studies and return results to patients for use in further research and development.</p>

Journal

  • Haigan

    Haigan 62 (1), 10-14, 2022-02-20

    The Japan Lung Cancer Society

Citations (1)*help

See more

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top