Clinical Features and Endoscopic Findings Detected in Patients with Eosinophilic Esophagitis During a Medical Check-up

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  • Takashima Shingo
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Nadatani Yuji
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University Department of Gastroenterology, Graduate School of Medicine, Osaka City University
  • Nishii Yuko
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Tauchi Yukie
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Otani Koji
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University
  • Tanaka Fumio
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University
  • Fujii Hideki
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Nakano Akemi
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Kimura Tatsuo
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Fukumoto Shinya
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University
  • Fujiwara Yasuhiro
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University
  • Watanabe Toshio
    Premier Preventive Medicine, Graduate School of Medicine, Osaka City University

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Other Title
  • 人間ドック受診を契機に発見された好酸球性食道炎の臨床像および内視鏡所見の検討
  • ニンゲン ドック ジュシン オ ケイキ ニ ハッケン サレタ コウサンキュウセイ ショクドウエン ノ リンショウゾウ オヨビ ナイシキョウ ショケン ノ ケントウ

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<p>Objective: This study aimed to elucidate the clinical features and endoscopic findings in patients with eosinophilic esophagitis (EoE) during a medical check-up.</p><p>Methods: This observational study was conducted on patients diagnosed with EoE during a physical examination at the MedCity21, Osaka City University, and randomly recruited age- and sex-matched healthy controls (1:1 ratio). Clinical characteristics, gastrointestinal endoscopic findings, and standard physical examination findings were analyzed using univariate analyses and compared between the patient and control groups, using multivariate logistic regression analyses for items with a p-value of < 0.1. Additionally, the detection rate of unique endoscopic findings in the patient group was also examined.</p><p>Results: A total of 94/20,145 participants were diagnosed with EoE, with a 0.47% detection rate. Longitudinal grooves were the most characteristic endoscopic findings of EoE observed in 93% of patients. Univariate analyses showed that the prevalence of alcohol consumption, dysphagia or heartburn symptoms, and serological allergy were significantly higher in the patient group than in the control group. Multivariate analyses indicated that alcohol consumption, dysphagia or heartburn symptoms, history of allergies, and the absence of Barrett’s esophagus were independent risk factors for EoE.</p><p>Conclusions: It is critical to evaluate the eosinophil count in the esophageal mucosa of patients with a history of allergic diseases and alcohol consumption, symptoms of choking or heartburn, and the absence of Barrett’s esophagus on endoscopic examination, to improve the EoE detection rate during a medical check-up.</p>

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