A case of thrombotic microangiopathy during chemotherapy with gemcitabine in a patient with pancreatic cancer
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- KASHIMA Hirotaka
- Department of Gastroenterology, Tenri Hospital
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- MINAMI Ryuki
- Department of Gastroenterology, Tenri Hospital
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- OZAWA Tomomi
- Department of Gastroenterology, Tenri Hospital
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- MATSUMOTO Atsushi
- Department of Gastroenterology, Tenri Hospital
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- KIMURA Yuto
- Department of Gastroenterology, Tenri Hospital
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- TAKEDA Yasuhiro
- Department of Gastroenterology, Tenri Hospital
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- UEO Taro
- Department of Gastroenterology, Tenri Hospital
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- OKANO Akihiro
- Department of Gastroenterology, Tenri Hospital
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- KUSUMI Fusako
- Department of Gastroenterology, Tenri Hospital
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- OHANA Masaya
- Department of Gastroenterology, Tenri Hospital
Bibliographic Information
- Other Title
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- 膵癌に対するGemcitabine療法中に発症した血栓性微小血管障害(TMA)の1例
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Abstract
<p>A 57-year-old male patient with unresectable pancreatic head cancer was treated with chemotherapy, 5 courses of gemcitabine plus nab paclitaxel therapy, and 9 courses of gemcitabine monotherapy. After 12 months of treatment, he was admitted to our hospital with headache and dyspnea. He was diagnosed with gemcitabine-induced thrombotic microangiopathy (TMA) due to acute kidney dysfunction, hemolytic anemia, and thrombocytopenia. Gemcitabine was discontinued, and symptoms were improved without using hemodialysis and plasma exchange. After his renal function recovered, we started S-1 chemotherapy. Eighteen months later, the patient was alive. Looking back, we realized that fragment red blood cells appeared in complete blood count and serum LDH elevated at 5 months prior to admission, serum creatinine level increased slowly at 4 months prior to admission, and blood pressure elevated significantly at 2 months prior to admission. Therefore, physicians must be aware of TMA as a possible adverse event to gemcitabine. As in this case, hemolytic findings and hypertension in patients treated with gemcitabine may help early detection of TMA.</p>
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 119 (3), 259-266, 2022-03-10
The Japanese Society of Gastroenterology
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Keywords
Details 詳細情報について
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- CRID
- 1390854717547045504
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- ISSN
- 13497693
- 04466586
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed