微視的薬物動態の解析手段としての非線形光学顕微鏡

DOI Web Site

書誌事項

タイトル別名
  • Nonlinear microscopic techniques for analyzing pharmacokinetics in microenvironment

抄録

<p>Spatiotemporal dynamics of drugs in tissues is a key determinant of their pharmacological actions. While such pharmacokinetics research has been performed at macroscopic level, those of microenvironment at cellular and subcellular scales could not have been assessed due to technical limitations. In this regard, nonlinear microscopic techniques have great potentials. With high spatiotemporal resolution provided by tissue penetrating ability of near infrared light and spatial restriction of nonlinear optical effects, multiphoton microscopy can reveal hidden phenomena inside tissues. In addition, various optical phenomena other than fluorescence can be utilized to image targets that cannot be labeled with and/or visualized by conventional fluorescence techniques. In this talk, I will introduce the basics of such imaging techniques as well as our attempts to utilize them for characterizations of pharmacokinetics as well as cellular responses in microenvironment at subcellular resolution.</p>

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ