書誌事項
- タイトル別名
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- Anatomical identification of segregated network modules of the retrosplenial cortex along the cingulate cortex
抄録
<p>The cingulate cortex, a brain region located from the genu of the corpus callosum to the splenium of the corpus callosum, is anatomically divided into anterior and posterior cingulate cortices (ACC and PCC, respectively). The ACC is involved in processing information for motor-related information and decision making, whereas the retrosplenial cortex (RSC), a region of the PCC, is involved in processing information such as memory and navigation. Accumulating evidence suggests that the ACC and RSC form neural circuits and integrate information, such as memory, navigation, and sensorimotor information, as well as contribute to symptoms of Alzheimer's disease. However, what information the RSC integrates from its presynaptic network and conveys to the ACC remains unknown. The purpose of this study is to identify a presynaptic network of ACC-projecting RSC neurons. Here we labeled ACC-projecting neurons in the anterior and posterior RSC (ACC-RSCa neurons and ACC-RSCp neurons, respectively) and their presynaptic neurons using adeno-associated viral vectors and rabies viral vectors. ACC-RSCa neurons and ACC-RSCp neurons received particular inputs among RSCa inputs and RSCp inputs, respectively. These results suggest that RSCa and RSCp neurons organize functionally segregated modules to convey particular information to the ACC.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 95 (0), 1-P-010-, 2022
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390854717648480768
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可