脳梁膨大後部皮質におけるネットワークモジュールの解剖学的同定

  • 上田 瑠南
    名古屋大・院創薬科学・基盤創薬学専攻
  • 正木 佑治
    名古屋大・院創薬科学・基盤創薬学専攻
  • 山口 真広
    名古屋大・院創薬科学・基盤創薬学専攻
  • 竹内 遼介
    名古屋大・院創薬科学・基盤創薬学専攻
  • 小坂田 文隆
    名古屋大・院創薬科学・基盤創薬学専攻 名古屋大・高等研究院・神経情報処理チーム 名古屋大・未来社会創造機構・ナノライフシステム研究所

書誌事項

タイトル別名
  • Anatomical identification of segregated network modules of the retrosplenial cortex along the cingulate cortex

抄録

<p>The cingulate cortex, a brain region located from the genu of the corpus callosum to the splenium of the corpus callosum, is anatomically divided into anterior and posterior cingulate cortices (ACC and PCC, respectively). The ACC is involved in processing information for motor-related information and decision making, whereas the retrosplenial cortex (RSC), a region of the PCC, is involved in processing information such as memory and navigation. Accumulating evidence suggests that the ACC and RSC form neural circuits and integrate information, such as memory, navigation, and sensorimotor information, as well as contribute to symptoms of Alzheimer&apos;s disease. However, what information the RSC integrates from its presynaptic network and conveys to the ACC remains unknown. The purpose of this study is to identify a presynaptic network of ACC-projecting RSC neurons. Here we labeled ACC-projecting neurons in the anterior and posterior RSC (ACC-RSCa neurons and ACC-RSCp neurons, respectively) and their presynaptic neurons using adeno-associated viral vectors and rabies viral vectors. ACC-RSCa neurons and ACC-RSCp neurons received particular inputs among RSCa inputs and RSCp inputs, respectively. These results suggest that RSCa and RSCp neurons organize functionally segregated modules to convey particular information to the ACC.</p>

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