書誌事項
- タイトル別名
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- Noradrenaline-induced basilar artery vasomotor response also varies in avian species (chickens and ducks)
抄録
<p>The basilar artery vasomotor response to noradrenaline (NA) differs between mammalian species (from α-receptor-mediated contraction in horses and β1 receptor-mediated relaxation in pigs and cattle, to no response in mice), but has not been similarly evaluated in avian species. Accordingly, we aimed to compare the NA-induced response in basilar arteries from two poultry species, the chicken and the duck, to further elucidate species variation in vasomotor mechanisms. </p><p>Method: We measured vasomotor responses to NA under resting tension and after precontraction with 5-hydroxytriptamine (5-HT) with and without phentolamine (PHEN; a non-selective α-antagonist) pretreatment. Isoproterenol (ISO; a non-selective β-agonist) was also applied. </p><p>Results: NA-treated chicken basilar arteries showed contraction under resting tension, and relaxation followed by weak contraction after precontraction with 5-HT; the latter response was augmented with PHEN pretreatment and the relaxation did not significantly differ from maximal ISO-induced relaxation. NA-treated duck basilar arteries showed no response under resting tension, and relaxation after precontraction with 5-HT; the latter response was not augmented with PHEN pretreatment and did not significantly differ from maximal ISO-induced relaxation. </p><p>Conclusion: We demonstrated that NA-induced basilar artery vasomotion response differs between these poultry species. Chicken basilar arteries might possess α > β1 receptors (involved in contraction and relaxation, respectively), and that duck basilar arteries might possess β1 receptors (involved in relaxation).</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 95 (0), 3-O-119-, 2022
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390854717648567040
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可