Influence of menstruation on the microbiota of healthy women’s labia minora as analyzed using a 16S rRNA gene‐based clone library method

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  • Shiraishi Tsukasa
    Life Science Laboratory, Unicharm Corporation, Japan
  • Fukuda Kazumasa
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health Japan, Japan
  • Morotomi Nobuo
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health Japan, Japan
  • Imamura Yuri
    Life Science Laboratory, Unicharm Corporation, Japan
  • Mishima Junko
    Life Science Laboratory, Unicharm Corporation, Japan
  • Imai Shigeo
    Life Science Laboratory, Unicharm Corporation, Japan
  • Miyazawa Kiyoshi
    Life Science Laboratory, Unicharm Corporation, Japan
  • Taniguchi Hatsumi
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health Japan, Japan

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  • Influence of Menstruation on the Microbiota of Healthy Women's Labia Minora as Analyzed Using a 16S rRNA Gene-Based Clone Library Method

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<p>The aim of this study was to determine the influence of menstruation on the bacterial population of healthy Japanese women's vulvas, especially the labia minora. Labia minora swabs were obtained from 10 premenopausal, nonpregnant Japanese women at premenstruation and on day 2 of menstruation. Vaginal swabs were also obtained from 3 out of the 10 women. No significant difference was found in the average bacterial cell count between the menstruation and premenstruation samples. Molecular analysis using a 16S rRNA gene-based clone library method detected 22 genera from the labia minora swabs (total 20), with the genus Lactobacillus being predominant at both premenstruation and during menstruation in 7 out of the 10 women. Of the other 3 women, 2 showed various kinds of bacterial species, including oral and fecal bacteria, with Atopobium vaginae and Gardnerella vaginalis predominating in the remaining woman's vulva in both conditions. In total, 6 out of 10 cases (60%) showed significantly different microbiota of the labia minora between the two conditions. These results imply that menstruation may promote a distortion of the bacterial flora around the vulva, although it causes no significant increase of the bacterial count.<tt> </tt></p>

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