A patient with pleomorphic anaplastic carcinoma TS1 diagnosed preoperatively by EUS-FNA

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  • UMEZAWA Saori
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine
  • KOBAYASHI Shinjiro
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine
  • NAKAHARA Kazunari
    Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine
  • MICHIKAWA Yousuke
    Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine
  • IDA Keisuke
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine
  • TSUCHIHASHI Atsuhito
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine
  • KOIZUMI Satoshi
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine
  • SATO Junya
    Department of Gastroenterology and Hepatology, St. Marianna University School of Medicine
  • KOIKE Junki
    Department of Pathology, St. Marianna University School of Medicine
  • OTSUBO Takehito
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine

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Other Title
  • EUS-FNAで術前に確定診断できたTS1の多形細胞型退形成癌の1例

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Abstract

<p>The patient is a female in her 70s referred for further workup after dilatation of the main pancreatic duct was seen on abdominal ultrasonography performed to evaluate cardiac orbital pain. Contrast-enhanced computed tomography scan showed an approximately 15mm contrast-enhancing mass in the pancreatic head. EUS-FNA was performed and revealed spindle-shaped cells, pleomorphic cells of unequal size, and atypical cells with osteoclast-like giant cells. These atypical cells were CD68 (KP-1) positive by immunostaining and diagnosed as anaplastic carcinoma of the pancreatic head. Pylorus preserving pancreaticoduodenectomy was performed. Histopathologic examination of the surgical specimen showed mainly pleomorphic cells, but also spindle-shaped cells and osteoclast-like giant cells, leading to the diagnosis of pT1c pleomorphic cell type anaplastic carcinoma TS1. The patient is currently alive and recurrence-free 9 months after resection. This patient had anaplastic carcinoma TS1 definitively diagnosed by preoperative EUS-FNA and resected.</p>

Journal

  • Suizo

    Suizo 37 (2), 104-111, 2022-04-28

    Japan Pancreas Society

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