電位計測型Solid-state biosensorの界面制御と分子認識検出

書誌事項

タイトル別名
  • Control of Interface Functions for Stable Molecular Detection based on Solid-state Biosensors
公開日
2022-05-01
DOI
  • 10.1541/ieejsmas.142.72
公開者
一般社団法人 電気学会

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説明

<p>We have been investigating functions of interfaces between different materials in potentiometric solid-state biosensors for stabilization of the electromotive forces (EMFs). The solid-state ion sensor showed a stable EMF only when the intermediate layer contained the primary ions and chloride ions. This indicated that an efficient ion exchange process was necessary at all interfaces involved, including a thin water layer, for a stable EMF of the solid-state ion sensor. A solid-state biosensor based on the organic and inorganic mixed phase modification of a silver surface was proposed as the second example. Stabilization of the EMF and functionalization with biomolecules on the sensing surface were simultaneously achieved using silver chloride and a self-assembled monolayer with oligonucleotide probes. The proposed schemes could be useful as stable solid-contacts for potentiometric sensor in biomedical fields such as liquid biopsy platforms and wearable sensors. </p>

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