Role of α-Fodrin Autoantigen in Sjögren’s Syndrome

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  • シェーグレン症候群における自己抗原α-Fodrinの役割
  • シェーグレン ショウコウグン ニ オケル ジコ コウゲンa-Fodrin ノ ヤクワリ

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Abstract

<p>The α-Fodrin N-terminal portion (AFN) autoantigen is involved in T cell-medicated autoimmune responses in patients with Sjögren’s syndrome. The infiltration of autoreactive T cells and the cleavage products of AFN were found in the salivary gland duct cells, and anti-AFN antibodies were detected in the serum of patients with Sjögren’s syndrome. The cleavage of α-Fodrin into the 120-kd fragment of AFN induced by Fas-mediated apoptosis and proliferative responses of T cells against AFN autoantigen were observed in the peripheral blood mononuclear cells of patients with Sjögren’s syndrome. AFN induced Th1-immune responses of T cells and accelerated downregulation of Fas-mediated T cell apoptosis in patients with Sjögren’s syndrome. These findings suggest that AFN autoantigen plays an important role in the development of Sjögren’s syndrome.</p>

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