Chronic Lymphocytic Leukemia with Plasmacytic Differentiation in a Cow

DOI Web Site 18 References
  • YOSHIZAKI Kojiro
    Kyoto Prefectural Chutan Livestock Hygiene Center
  • MANDOKORO Kouki
    Kyoto Prefectural Chutan Livestock Hygiene Center
  • MIKAMI Osamu
    Sapporo Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization
  • ISHIKAWA Yoshiharu
    Sapporo Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization
  • KADOTA Koichi
    Sapporo Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization

Bibliographic Information

Other Title
  • 牛の形質細胞への分化を伴う慢性リンパ性白血病の1例

Search this article

Abstract

<p>A case of chronic lymphocytic leukemia (CLL) with plasmacytic differentiation was detected in a 5-year-old Holstein cow not infected with bovine leukemia virus. Generalized lymph node swelling was due to proliferation of tumor cells, and perivascular tumor cell infiltration or accumulation was observed in various sites of the body. Neoplastic cells were polymorphic, being divided into lymphoid and plasmacytoid cells. These cells were positive for CD20 and CD5, and plasmacytoid cells showed positive reactivity for cytoplasmic immunoglobulin M (cIgM) (μ chain and λ chain). In some parts, cIg-negative large lymphoid cells accumulated into clusters, and this implies a histological shift of CLL to large cell lymphoma (large cell transformation). This lymphoma with CD5 expression and relatively scant cytoplasm in plasmacytoid cells was readily distinguishable from lymphoplasmacytic lymphoma characterized by CD5 negativity and abundant cytoplasm in neoplastic plasma cells.</p>

Journal

References(18)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top