Rapidly Growing Large Angiomyofibroblastoma of the Vulva: A Case Report and Review of 215 Reported Cases of Angiomyofibroblastoma in the Literature

Hasegawa Michiko, Saito Ryuichi, Tamura Atsushi

doi:10.14924/dermatol.132.1471

<p>Angiomyofibroblastoma is a rare, benign, slowly growing, mesenchymal tumor that occurs mainly in the female vulva. It can be easily misdiagnosed as aggressive angiomyxoma; both tumors share some clinicopathological features, including a preferential location on the vulva and hypocellular pathology. We report a 53-year-old woman with a vulvar mass of 3 years' duration that had rapidly enlarged over the previous year. Physical examinations revealed a 10×8×8-cm pedunculated flesh-colored tumor on the right labium majus. The surgically excised tumor was well-circumscribed without invasion of the surrounding tissue. Histopathologically, the tumor showed alternating hypercellular and hypocellular areas accompanied by vascular hyperplasia. The hypercellular areas consisted of spindle to ovoid tumor cells proliferating in a collagenous stroma. In hypocellular areas, small vessels were scattered in an edematous, loosely arranged collagenous stroma. The clinical and histopathological features were consistent with the diagnosis of angiomyofibroblastoma of the vulva. We reviewed 215 reported cases of angiomyofibroblastoma from 1992 to 2021 in the literature and found that large growth and rapid enlargement simulating an aggressive angiomyxoma are not rare in angiomyofibroblastoma. Therefore, large vulvar tumors should be carefully managed by pre- and intraoperative examinations to avoid oversurgery.</p>

Rapidly Growing Large Angiomyofibroblastoma of the Vulva: A Case Report and Review of 215 Reported Cases of Angiomyofibroblastoma in the Literature

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