Evaluation of Concentrations of Polidocanol for Sclerotherapy in the Treatment of Varicose Veins

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  • Satokawa Hirono
    Department of Cardiovascular Surgery, Fukushima Medical University School of Medicine
  • Hoshino Shunichi
    Department of Cardiovascular Center, Fukushima First Hospital
  • Sakaguchi Shukichi
    Honorary Professor, Hamamatsu University School of Medicine
  • Ito Katuro
    Department of Surgery, Matsue Municipal Hospital
  • Hirai Masafumi
    Department of Surgery, Aichi Prefectural College of Nursing
  • Sasaki Hisao
    Department of Clinical Research, National Kanazawa Hospital
  • Hori Goichi
    Department of Cardiovascular Surgery, Showa University Fujigaoka Hospital
  • Iwai Takehisa
    Division of Vascular Surgery, Department of Surgery, Tokyo Medical and Dental University
  • Orii Masahiro
    First Department of Surgery, Tokai University
  • Yokoyama Hitoshi
    Department of Cardiovascular Surgery, Fukushima Medical University School of Medicine

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  • 下肢静脈瘤硬化療法における硬化剤（ポリドカノール）の至適濃度の検討

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<p>To clarify the best suited concentrations of Polidocanol (POL) for sclerotherapy in the treatment of varicose veins, a prospective multicenter study was conducted. Between February 1995 and May 1997, 259 patients were divided into three groups; less than 1mm in the diameter of varicosity (group 1), from 1mm to 3mm (group 2), and over than 3mm (group 3). The POL concentration was decided by lot and compression sclerotherapy was performed. POL concentrations were selected among 0.25%, 0.5 % and 1.0% in group 1, 0.5%, 1.0 %, 2.0% in group 2, 2.0%and 3.0 % in group 3. There was no difference in the disappearance rate of varicose veins between 0.5% and 1.0% in group 1, and between 1.0% and 2.0% in group 2. The disappearance rate of 0.5% was higher than 0.25% in group 1 (p<0.05). The rate of 1.0% was higher than 0.5 % in group 2, and the one of 3.0% was higher than 2.0% in group 3 (p<0.05). There were no complications. The localized side effects were intravariceal thrombosis of 30.9% and pigmentation of 27.0%. Clinical examinations revealed that RBC, Hb and Ht were slightly decreased after treatment. In conclusion, the best suited concentration of POL is 0.5% for less than 1mm varicose vein, 1.0% for over than 1mm and less than 3mm, and 3.0% for over than 3mm in the treatment of varicose veins.</p>

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