Aging-Related Alteration in Cell Size Distribution in the Stratum Corneum and Its Relationship with Facial Appearance

Morita Miho, Horitsuji Mai

doi:10.5107/sccj.56.121

<p>Studies on the changes in facial appearance with age, such as wrinkle formation and skin sagging, have revealed chronological alterations in the physical properties of the deep skin. However, the association of the skin surface with the changes in facial appearance has not been clarified yet, even though the external appearance is related to the surface elements. In this study, we investigated the phenomena occurring on the skin surface in association with the morphological changes on the face by observing the surface area, degree of skin folding, stratum corneum (SC) cell size, and skin motion in half of the face. Our results revealed that the enlargement of the facial surface area with aging and concomitant wrinkle formation are accompanied by changes in the size of SC cells. Additionally, the degree of skin movement during facial expressions exhibited a significant correlation with SC cell size distribution in the older individuals. These observations suggest that the skin surface undergoes morphological modifications by changing the size and distribution of SC cells in relation to the specific motion of each area. Repetitive stretch of the eye corner skin reduced the difference in SC cell size and improved wrinkles. Therefore, skin movement contributes to both the development and improvement of changes in SC cell size distribution. In conclusion, SC cell size and its macroscopic distribution can be considered as a novel and important target for morphological anti-aging, and these findings will help to enhance the application of cosmetics.</p>

Aging-Related Alteration in Cell Size Distribution in the Stratum Corneum and Its Relationship with Facial Appearance

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