A case of pulmonary thromboembolism occurring during chemotherapy for oral cancer

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  • SHIBATA Akane
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • SHIMO Tsuyoshi
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
  • KISHIMOTO Koji
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • KUNISADA Yuki
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • MESE Hiroshi
    Department of Oral and Maxillofacial Surgery, Fukuyama City Hospital
  • SASAKI Akira
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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  • 口腔癌の化学療法中に発症した肺血栓塞栓症の1例
  • コウクウ ガン ノ カガク リョウホウ チュウ ニ ハッショウ シタ ハイ ケッセン ソクセンショウ ノ 1レイ

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Abstract

<p>In addition to cancer-bearing status, chemotherapy is one of the moderate risk factors for the development of thromboembolism. However, there are few reports about it for oral cancer. Here, we report a case of pulmonary thromboembolism (PTE) that developed during chemotherapy for oral cancer. The patient was a 59-year-old man with left maxillary gingival cancer (T2N2bM0, Stage ⅣA). He complained of chest pain and dyspnea on the third day of the first course of TPF (docetaxel, cisplatin, 5-FU), which was performed as preoperative chemotherapy. Therefore, we performed an electrocardiogram and contrast-enhanced CT imaging. ST elevation, tachycardia and atrial fibrillation were observed on the electrocardiogram. PTE was also observed in his left lung in CT images. We immediately started the administration of β -blocker and anticoagulant therapies. After that the patient’s subjective symptoms disappeared and the electrocardiogram showed stability two days later. Therefore, chemotherapy was continued and completed. After three weeks, a left maxillary partial resection and left radical neck dissection were performed. Following the operation, there have been no PTE symptoms and he is making good progress.</p>

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