A Case of Curative Resection of a Small Bowel Gastrointestinal Stromal Tumor with Peritoneal Dissemination That Responded to Long-Term Imatinib Mesylate Therapy

DOI Web Site 21 References
  • Shinohara Yoshihito
    Department of General Surgery, Yoichi Kyokai Hospital
  • Noji Takehiro
    Department of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University
  • Kuramae Taro
    Department of General Surgery, Yoichi Kyokai Hospital
  • Yoshida Hideaki
    Department of General Surgery, Yoichi Kyokai Hospital
  • Tobioka Hirotoshi
    Department of Pathology, Otaru Kyokai Hospital
  • Hirano Satoshi
    Department of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University

Bibliographic Information

Other Title
  • 長期イマチニブ療法にて播種病変が消失した小腸gastrointestinal stromal tumorの1切除例

Search this article

Abstract

<p>A 55-year-old man was admitted to our hospital with a complaint of abdominal distension. Contrast-enhanced CT showed a 14-cm mass in the upper left abdomen and a 17-cm mass in the pelvic cavity, as well as numerous intra-abdominal nodules. A percutaneous needle biopsy was performed for the upper abdominal tumor, and gastrointestinal stromal tumor (GIST) with multiple peritoneal dissemination was diagnosed. Imatinib mesylate therapy was started, and after two years of this therapy, the tumors in the upper left abdomen and pelvic cavity had shrunk to 6 cm and 8 cm, respectively. Five years after the start of the therapy, exploratory laparoscopy and biopsy of the disseminated lesions were performed. The biopsy showed no residual tumor and PET-CT showed no accumulation. We judged that radical resection was possible, and surgery was performed. A histopathological examination revealed a 5-mm c-kit positive tumor in the muscularis propria of the upper jejunum. All other lesions were calcification and fibrous tissue only. Postoperative imatinib was continued and there has been no recurrence for 24 months after the surgical resection.</p>

Journal

References(21)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top