Quiescent B Cells Acquire Sensitivity to Cell Cycle Arresting Agents by B Cell Receptor Stimulation
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- Hosokawa Takanatsu
- Graduate School of Systems Life Sciences, Kyushu University
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- Tanaka Shinya
- Division of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University
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- Mori Takeshi
- Graduate School of Systems Life Sciences, Kyushu University Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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- Baba Yoshihiro
- Division of Immunology and Genome Biology, Medical Institute of Bioregulation, Kyushu University
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- Katayama Yoshiki
- Graduate School of Systems Life Sciences, Kyushu University Department of Applied Chemistry, Faculty of Engineering, Kyushu University International Research Center for Molecular Systems, Kyushu University Center for Advanced Medical Innovation, Kyushu University Department of Biomedical Engineering, Chung Yuan Christian University
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説明
<p>For the treatment of autoimmune diseases, depletion of B cells specific for auto-antigens is important because they will be a source of plasmablasts/plasma cells to produce autoantibodies. However, because some types of B cells like naïve B cells and memory B cells are at quiescent phase, they are insensitive to anticancer drugs which exert cytotoxicity by arresting the cell cycle. Here we show that B cell receptor (BCR) stimulation increases the sensitivity of anticancer drugs by promoting the proliferation of quiescent B cells. The BCR stimulation to primary naïve B cells enhanced sensitivity to several anticancer drugs which arrest the cell cycle through different mechanisms. The present results indicated that combination of the BCR stimulation and anticancer drugs is a promising strategy for the antigen-specific depletion of pathogenic quiescent B cells.</p>
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 45 (7), 847-850, 2022-07-01
公益社団法人 日本薬学会