Comparison of Helium-Alternative Carrier Gases for Gas Chromatography/Mass Spectrometry of Standard Test Methods for Indoor Air Quality Guidelines in Japan

DOI Web Site 参考文献7件 オープンアクセス
  • Oshima Naohiro
    Division of Environmental Chemistry, National Institute of Health Sciences
  • Takagi Mihono
    Division of Environmental Chemistry, National Institute of Health Sciences
  • Sakai Shinobu
    Division of Environmental Chemistry, National Institute of Health Sciences
  • Ikarashi Yoshiaki
    Division of Environmental Chemistry, National Institute of Health Sciences

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説明

<p>Helium is the most frequently used carrier gas for GC/MS, which is the official standardized test method in Japan to assess chemical substances in indoor air. However, recent global challenges in the supply chain for helium have led to a need to validate GC/MS using alternative carrier gases. In this study, we examined the applicability of hydrogen and nitrogen as helium-alternative carrier gases in the standardized GC/MS analytical test method for volatile organic compounds (VOC) and phthalate esters in indoor air. Comparison of the signal-to-noise ratios of standard solutions showed that detection sensitivities of hydrogen and nitrogen analysis were enough for the standard test method, although these gases, especially nitrogen, were less sensitive than helium. Measurements using these alternative carrier gases showed good linearity and could quantify around 1/100th of Japanese guideline values for indoor air concentrations. Therefore, hydrogen and nitrogen gases can be applied to the standard GC/MS analysis test method for VOC and phthalate esters in indoor air as alternative carrier gases to helium.</p>

収録刊行物

  • BPB Reports

    BPB Reports 5 (4), 84-87, 2022

    公益社団法人 日本薬学会

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