Metronomic Photodynamic Therapy Using an Implantable Green Color LED Device and Orally Administered 5-Aminolevulinic Acid

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  • Kirino Izumi
    Department of Physiology, National Defense Medical College Division of Hepatobiliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University
  • Sugita Rin
    Department of Life Science and Medical Bio-Science, Waseda University
  • Yamagishi Kento
    Digital Manufacturing and Design (DManD), Singapore University of Technology and Design
  • Fujie Toshinori
    School of Life Science and Technology, Tokyo Institute of Technology
  • Sakanoue Kei
    Pleiades Technologies LLC
  • Fujita Katsuhiko
    Institute for Materials Chemistry and Engineering, Kyushu University
  • Takeoka Shinji
    Department of Life Science and Medical Bio-Science, Waseda University
  • Morimoto Yuji
    Department of Physiology, National Defense Medical College

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  • 5-アミノレブリン酸と生体埋め込み型の緑色光LEDデバイスを用いたメトロノミックPDTによる抗腫瘍効果

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<p>Metronomic photodynamic therapy (mPDT) initiates cancer cell death by intermittent continuous irradiation with low power light for extended durations (several days). We developed a wireless powered, fully implantable LED device capable of transmitting significant anti-tumor effects of mPDT. Considering application to clinical practice, repeated intravenous administration of photosensitizers for mPDT may increase the patient’s burden. Therefore, in this study, 5-aminolevulinic acid (ALA) was selected to be administered orally as a photosensitizer, and studied the anti-tumor effects of mPDT. In the mice intradermal tumor model, with orally administered ALA (200 mg/kg daily for five days), the tumor in each mouse was irradiated (8 h/day for five days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in mPDT-treated mice was suppressed by about half compared to untreated mice. Results proved mPDT using the wirelessly powered implantable LED device with orally administered ALA displayed significant anti-tumor effects. This treatment regimen could reduce the burden of photosensitizer administration for a patient.</p>

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