Proteomic analysis of NAFLD mice liver mitochondria following exposure to hepatotoxic drug

DOI
  • HAMADA Kazuma
    Biopharmaceutics and Molecular Toxicology Unit, Faculty of Pharmaceutical Sciences, Teikyo Heisei University
  • MIZUMA Takashi
    Biopharmaceutics and Molecular Toxicology Unit, Faculty of Pharmaceutical Sciences, Teikyo Heisei University

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Other Title
  • ミトコンドリアプロテオーム解析によるNAFLDの薬物性肝障害の解明

Abstract

<p>Mitochondrial permeability transition (MPT) in response to stress allows leakage of mitochondrial molecules, which can lead to a variety of biological phenomena including cell death and inflammation. We have previously shown that liver mitochondria in non-alcoholic fatty liver disease (NAFLD) are more susceptible to hepatotoxic drug induced MPT. In this study, we aimed to identify the molecules released from NAFLD mitochondria upon MPT induction and to describe the biological events triggered by MPT. Our proteomic analysis showed that sirtuin signaling, HSP90 signaling, autophagy-related protein signaling, mitochondrial dynamics, mTOR signaling, and ROS signaling are likely to be involved in the MPT-mediated events that occur in NAFLD liver.</p>

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