Effects of Dietary Vitamin D Deficiency on Markers of Skeletal Muscle Mitochondrial Biogenesis and Dynamics

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  • RA Song-Gyu
    Laboratory of Exercise Nutrition and Biochemistry, Faculty of Sports and Health Science, Fukuoka University Fukuoka Univerity Institute for Physical Activity Institute of Liberal Arts and Sciences, Tokushima University
  • NAKAGAWA Hironari
    Laboratory of Exercise Nutrition and Biochemistry, Faculty of Sports and Health Science, Fukuoka University
  • TOMIGA Yuki
    Fukuoka Univerity Institute for Physical Activity Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University Japan Society for the Promotion of Science
  • IIZAWA Hiroki
    Laboratory of Exercise Nutrition and Biochemistry, Faculty of Sports and Health Science, Fukuoka University
  • NAKASHIMA Shihoko
    Fukuoka Univerity Institute for Physical Activity
  • HIGAKI Yasuki
    Fukuoka Univerity Institute for Physical Activity Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University
  • KAWANAKA Kentaro
    Laboratory of Exercise Nutrition and Biochemistry, Faculty of Sports and Health Science, Fukuoka University Fukuoka Univerity Institute for Physical Activity

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<p>We examined the effects of dietary vitamin D deficiency on markers of mitochondrial biogenesis and dynamics in rat soleus muscle. Male Wistar rats were fed a chow with no vitamin D (No-D; 0 IU/kg) or a moderate dose (Mod-D; 2,000 IU/kg) of vitamin D chow for 8 wk. Compared to the Mod-D group, at 8 wk the No-D group showed significantly lower serum 25(OH)D levels. Although vitamin D deficiency had no effect on body composition, the No-D rats showed significantly decreased levels of PGC-1α, a marker of skeletal muscle mitochondrial biogenesis, and DRP1, a marker of skeletal muscle mitochondrial fission. The change in the PGC-1α protein expression and the serum 25(OH)D concentrations were significantly correlated. The change in DRP1 protein expression and the serum 25(OH)D concentrations tended to be correlated. There was no significant between-group difference in markers of mitochondrial fusion (MFN2 and OPA1) and mitophagy (PARKIN) in soleus muscle, and no relationship with serum 25(OH)D concentrations. Collectively our findings suggest that dietary vitamin D deficiency decreased PGC-1α and DRP1 protein expression in rat soleus muscle.</p>

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