Combined Experimental Paradigm of Psychosocial Stress and Pain in Animal Models

DOI
  • Saitoh Hidetoshi
    Department of Pharmacology, School of Pharmacy at Fukuoka, International University of Health and Welfare

Bibliographic Information

Other Title
  • 動物モデルを用いた心理社会的ストレスと痛みの科学的理解へのアプローチ

Abstract

<p>Pain is a physical and emotional experience. Physical pain and social factors have a complex and mutual relationship. Basic research using rodent models has advanced the understanding of factors involved in pathological and non-pathological pain and contributed to the development of various drugs. However, to reveal the interactions among pain, mental activity, and the psychosocial environment, it is necessary to develop proper experimental paradigms.</p><p>We established a new experimental protocol combining a chronic pain model and social defeat stress model and investigated the effect of stress load on the chronic pain model. The recurrence of pain pathology was caused by social defeat stress. We also recorded an increase in the levels of inflammatory cytokines in the plasma by stress loading and showed that the administration of inflammatory substances caused pain recurrence. Additionally, spinal cord microglial reactivation was observed after stress loading and systemic inflammation.</p><p>Taken together, we suggest that microglial reactivation, correlated with the systemic inflammatory response after stress loading, is involved in the pathology of refractory pain.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390856218602606080
  • DOI
    10.15064/jjpm.62.5_385
  • ISSN
    21895996
    03850307
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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