Comparison of the preventive effects of neuromuscular electrical stimulation and pulsed magnetic stimulation on disuse atrophy in rat soleus muscle

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  • Nakanishi Ryosuke
    Faculty of Rehabilitation, Kobe International University
  • Hirayama Yusuke
    Graduate School of Health Sciences, Kobe University
  • Tanaka Minoru
    Graduate School of Health Sciences, Kobe University Department of Health Sciences, Osaka Health Science University
  • Ono Kohei
    Graduate School of Health Sciences, Kobe University
  • Ikeji Takuya
    Graduate School of Health Sciences, Kobe University
  • Maeshige Noriaki
    Health Sciences Discipline, Life and Medical Sciences Area, Kobe University
  • Fujino Hidemi
    Health Sciences Discipline, Life and Medical Sciences Area, Kobe University

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  • 廃用性筋萎縮に対する神経筋電気刺激とパルス磁気刺激の比較検証
  • ハイヨウセイキン イシュク ニ タイスル シンケイキン デンキ シゲキ ト パルス ジキ シゲキ ノ ヒカク ケンショウ

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Abstract

<p>Neuromuscular electrical stimulation (NMES) is an effective intervention for prevention of muscle atrophy via muscle contraction. Despite the fact that pulsed magnetic stimulation (MS) is also a muscle contraction method, no studies have compared NMES and MS for the prevention of muscle atrophy. Therefore, this comparative study investigated the effects of NMES and MS on the prevention of muscle atrophy via the inhibition of muscle-specific ring finger protein-1 (MuRF-1) of the ubiquitin-proteasome protein degradation pathway in rat soleus muscle. Male Sprague-Dawley rats were assigned randomly either to a control (CON), or to one of three groups: 2 weeks hindlimb unloading (HU), HU plus NMES on the left calf muscles (HU+NMES), or HU plus MS on the right calf muscles (HU+MS). Muscle mass, relative weight ratio, fiber cross-sectional area (FCSA), and MuRF-1 expression were examined in the soleus muscles of all rats. HU resulted in a decrease in the FCSA and an increase in the MuRF-1 expression. Meanwhile, NMES attenuated an increase in MuRF-1 expression and a decrease in the FCSA caused by unloading. Furthermore, MS significantly reduced the expression level of MuRF-1 protein, resulting in an increase of the FCSA. These results suggest that MS could prevent muscle atrophy via inhibiting MuRF-1, but NMES was insufficient to prevent atrophy.</p>

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