A Case of Pityriasis Rubra Pilaris Successfully Treated with Apremilast

DOI
  • Yamane Nanako
    Department of Dermatology, Kindai University Faculty of Medicine
  • Suzuki Midori
    Department of Dermatology, Kindai University Faculty of Medicine
  • Kato Maiko
    Department of Dermatology, Kindai University Faculty of Medicine
  • Yanagihara Shigeto
    Department of Dermatology, Kindai University Faculty of Medicine
  • Oiso Naoki
    Department of Dermatology, Kindai University Faculty of Medicine
  • Kawada Akira
    Department of Dermatology, Kindai University Faculty of Medicine
  • Otsuka Atsushi
    Department of Dermatology, Kindai University Faculty of Medicine

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Other Title
  • アプレミラストが著効した毛孔性紅色粃糠疹の 1 例

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Abstract

<p>A-71-year-old Japanese man was referred to our department because of slightly pruritic eruptions on the face for 2 months. Clinically, scaly erythematous macules and vesicles were scattered on the face, trunk, and extremities. We diagnosed as pityriasis rubra pilaris type 1 based on histopathological examination and clinical findings. The eruptions persisted despite topical application of corticosteroids and vitamin D3 analogues ; however, additional oral administration of etretinate and cyclosporine improved his symptoms. Recurrent lesions developed after stopping administration of etretinate and cyclosporine. The lesions improved after oral administration of apremilast, a phosphodiesterase 4 inhibitor, with topical corticosteroids and vitamin D3 analogues for 5 weeks. Apremilast may be an effective drug for pityriasis rubra pilaris type 1 via antiinflammatory reaction, even though the possibility of spontaneous disappearance may remain. More accumulated case series are needed to confirm the efficacy of phosphodiesterase inhibitors for pityriasis rubra pilaris type 1. Skin Research, 21 : 103-107, 2022 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 21 (2), 103-107, 2022

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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