Retrospective analysis of clinical and pathological findings of 12 heterozygous calves with cholesterol deficiency-like symptoms

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  • Kudo S.
    Shibecha Veterinary Clinical Center, Eastern Hokkaido Agricultural Mutual Aid Association
  • Moriyama S.
    Central Research Institute for Feed and Livestock, ZEN-NOH
  • Watanabe K.
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Horiuchi N.
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Kobayashi Y.
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Inokuma H.
    Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, the University of Tokyo

Bibliographic Information

Other Title
  • コレステロール代謝異常症様症状を呈したヘテロ子牛12頭の臨床および病理所見の回顧的解析
  • コレステロール タイシャ イジョウショウ ヨウ ショウジョウ オ テイシタ ヘテロ コウシ 12トウ ノ リンショウ オヨビ ビョウリ ショケン ノ カイコテキ カイセキ

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Abstract

<p>　To better understand the pathophysiology of heterozygosity for cholesterol deficiency（CD）in Holstein cattle, clinical and necropsy findings of 12 heterozygous calves with chronic diarrhea and/or muscle atrophy were retrospectively analyzed and compared to those of 29 homozygous calves. As a result, frequencies of chronic diarrhea, muscle atrophy, fever, and loss of appetite were not significantly different between these groups. Serum total cholesterol was significantly higher in heterozygous carriers（median, 29 mg/dℓ）than in homozygous calves（median, 8 mg/dℓ）. Red blood cell count, hemoglobin, hematocrit, and mean corpuscular volume were all significantly higher in heterozygous carriers than in homozygous calves, but white blood cell count, total protein concentration,aspartate aminotransferase, and lactate dehydrogenase were not significantly different. Pathologically abnormal findings such as pneumonia, pleuritis, funisitis, and cardiac malformations were significantly more frequently recorded in heterozygous animals（50%）than in homozygous animals（10%）. These findings suggest that the CD-like symptoms observed in the heterozygous calves were more likely caused by organic lesions rather than hypocholesterolemia. However, one of the two heterozygous calves with markedly low serum total cholesterol（<15 mg/dℓ）had no organic lesions except for esophageal ulcer that was similar to those observed in homozygous animals. Therefore, the development of CD-associated symptoms cannot be completely ruled out in heterozygous carriers.</p>

Journal

  • Japanese Journal of Large Animal Clinics

    Japanese Journal of Large Animal Clinics 12 (1), 8-12, 2021-04-30

    Japanese Society of Large Animal Clinics / Large Animal Clinic Research Association / Kyushu-Okinawa Society for Large Animal Medicine

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