Generation of Microbubble-Encapsulated Vesicles with Flow Focusing Device and Inverted Emulsion Method

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  • フローフォーカス型流路と油水界面通過法によるマイクロバブル内包ベシクルの生成

Abstract

<p>Microbubble-Encapsulated Vesicle (MEV) is one of the drug carriers which is used for cancer treatment with Drug Delivery System (DDS). MEVs need to be smaller than 5 μm and uniform size in order to pass through capillaries and to be ultrasonic controlled. In this study, we tried to generate MEVs satisfying these requirements by using a flow focusing device and an inverted emulsion method. In conclusion, we succeeded in generating 5 μm MEVs with this method, although vesicles not satisfying the requirements were also generated. In the future work, it is necessary to enhance the rate of microbubble encapsulation.</p>

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