Association between obesity and gene polymorphisms (<i>ADRB3</i>, <i>HTR2A</i>, <i>NOS1</i>)

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  • KONGO Sakyo
    Graduate School of Environmental Health, Azabu University
  • MIKAMI Marina
    Graduate School of Environmental Health, Azabu University
  • AOKI Rie
    Graduate School of Environmental Health, Azabu University
  • NAGATANI (NUMAJIRI) Maki
    Department of Medical Technology, School of Life and Environmental Science, Azabu University
  • NISHIZAWA Daisuke
    Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science
  • IKEDA Kazutaka
    Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science
  • IWAHASHI Kazuhiko
    Graduate School of Environmental Health, Azabu University Department of Medical Technology, School of Life and Environmental Science, Azabu University
  • ONOZAWA Yuya
    Department of Medical Technology, School of Life and Environmental Science, Azabu University

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Other Title
  • 肥満と遺伝子多型（<i>ADRB3</i>, <i>HTR2A</i>, <i>NOS1</i>）の関連性についての検討
  • 肥満と遺伝子多型(ADRB3, HTR2A, NOS1)の関連性についての検討
  • ヒマン ト イデンシ タケイ(ADRB3, HTR2A, NOS1)ノ カンレンセイ ニ ツイテ ノ ケントウ

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Abstract

<p>Obesity is a risk factor for many diseases, including diabetes mellitus, the incidence of which has nearly tripled since 1975, and is known to be caused by dietary and other lifestyle-related diseases as well as genetic factors. In this study, to elucidate the effects of genetic factors on individual differences in obesity vulnerability, I focused on four SNPs, including functional polymorphisms of ADRB3 (rs4994), HTR2A (rs6311, rs6313), and NOS1 (rs2682826), and compared the differences in the frequencies of these polymorphisms between nine obese subjects (BMI ≥ 25) and 51 non-obese subjects (BMI < 25) living in a Japanese prefecture. There was no significant difference in the allelic frequency of each SNP between the obese and non-obese groups. In addition, analysis of the combinations of gene polymorphisms showed that they were not associated with the risk of diabetes. Therefore, ADRB3 (rs4994), HTR2A (rs6311, rs6313), and NOS1 (rs2682826) gene SNPs do not appear to be risk factors for obesity.</p>

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