A case of severe Henoch-Schönlein purpura nephritis refractory to treatment due to prolonged ocular hypertension caused by steroids

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  • ステロイド性高眼圧症の遷延により，治療に難渋した重症紫斑病性腎炎の1例

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<p>We hereby report a case of severe Henoch-Schönlein purpura nephritis (HSPN). The patient was treated using a multidrug combination regimen, which included steroid pulse therapy. However, the steroid-induced intraocular pressure increased early on, requiring modification of the treatment. Surgical treatment for steroid-induced intraocular hypertension could be avoided through early reduction of corticosteroids and use of multiple ophthalmic medications. In addition, nephritis was treated by switching to combination of multiple immunosuppressive agents (mizoribine, cyclosporine, and cyclophosphamide), which resulted in negative urine dipstick tests. In this case, it was possible to avoid ocular complications while treating nephritis by administration of appropriate steroid-induced intraocular hypertension medications and concomitant use of effective immunosuppressive agents.</p>

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