熱分析による非晶質医薬品の結晶化の評価
書誌事項
- タイトル別名
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- Evaluation of Crystallization of Amorphous Drugs by Thermal Analysis
- ネツ ブンセキ ニ ヨル ヒショウシツ イヤクヒン ノ ケッショウカ ノ ヒョウカ
- 公開日
- 2011-08-31
- DOI
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- 10.11311/jscta.38.4_125
- 公開者
- 日本熱測定学会
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説明
About half of candidates for active pharmaceutical ingredients are poorly water soluble compounds. Amorphization of poorly water soluble drugs has attracted much attention due to improved dissolution characteristics and bioavailability of amorphous drugs. On the other hand, crystallization during storage is of concern for amorphous drugs. Therefore, evaluation of crystallization of amorphous drug is important for developing stable pharmaceuticals using amorphous drugs. In this article, feasibility of thermal method such as differential scanning calorimeter and isothermal microcalorimeter for evaluating crystallization of amorphous drugs and research topics on the crystallization of amorphous drug are described.
収録刊行物
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- 熱測定
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熱測定 38 (4), 125-131, 2011-08-31
日本熱測定学会
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詳細情報 詳細情報について
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- CRID
- 1390857136555658752
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- NII論文ID
- 10029867718
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- NII書誌ID
- AN00199597
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- ISSN
- 18841899
- 03862615
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- NDL書誌ID
- 11233316
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可