Short-Term Outcomes of Magnetically Levitated Left Ventricular Assist Device in Advanced Heart Failure　― The Japanese Cohort ―

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  • Inoue Koichi
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Fujita Tomoyuki
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Yoshioka Daisuke
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Tonai Kohei
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Yanagino Yusuke
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Kakuta Takashi
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Tadokoro Naoki
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Kawamoto Naonori
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Yamashita Kizuku
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Kawamura Ai
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Matsuura Ryohei
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Kawamura Takuji
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Saito Tetsuya
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Kawamura Masashi
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Kainuma Satoshi
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Fukushima Satsuki
    Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center
  • Toda Koichi
    Department of Cardiovascular Surgery, Osaka University Hospital
  • Miyagawa Shigeru
    Department of Cardiovascular Surgery, Osaka University Hospital

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<p>Background: The superiority of a fully magnetically levitated centrifugal-flow left ventricular assist device (LVAD) in terms of overall survival, stroke events and pump thrombosis has been demonstrated in previous international analyses, so we evaluated a Japanese cohort for the same.</p><p>Methods and Results: This retrospective observational study was conducted at Osaka University Medical Hospital and the National Cerebral and Cardiovascular Center in Japan. A total of 75 consecutive patients who underwent HeartMate3 (HM3) implantation were included. The primary endpoint was on-device survival, and the secondary endpoint was the incidence of LVAD-related complications at 2 years. All parameters were compared with those of the previously performed HeartMate II (HMII) implantation in 197 cases. The on-device survival rates were 94.7% and 92.3% in the HM3 and HMII groups, respectively, at the 2-year follow-up (P=0.62). The rehospitalization-free rate after implantation was 61.8% in the HM3 group, which was significantly higher than that in the HMII group (relative risk, 0.35; 95% confidence interval [CI], 0.23–0.55; P<0.0001). Event-free survival rates from cerebral cerebrovascular events and pump thrombosis in the HM3 group were significantly higher than those in the HMII group, at 97.2% and 100%, respectively (relative risk, 0.14; 95% CI 0.03–0.58); P=0.0015 and relative risk, not calculated; P=0.049, respectively).</p><p>Conclusions: Satisfactory short-term outcomes were observed after HM3 implantation in a Japanese cohort.</p>

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  • Circulation Journal

    Circulation Journal 86 (12), 1961-1967, 2022-11-25

    一般社団法人 日本循環器学会

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