Whole-genome sequencing analysis of wild house mice (<i>Mus musculus</i>) captured in Madagascar
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- Fujiwara Kazumichi
- Graduate School of Information Science and Technology, Hokkaido University
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- Ranorosoa Marie C.
- Ecole Supérieure des Sciences Agronomiques, Université d’Antananarivo
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- Ohdachi Satoshi D.
- Institute of Low Temperature Science, Hokkaido University Graduate School of Environmental Science, Hokkaido University
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- Arai Satoru
- Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases
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- Sakuma Yuki
- Graduate School of Environmental Science, Hokkaido University
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- Suzuki Hitoshi
- Graduate School of Environmental Science, Hokkaido University
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- Osada Naoki
- Graduate School of Information Science and Technology, Hokkaido University
抄録
<p>In Madagascar, the house mouse (Mus musculus) is widely believed to have colonized with human activities and is now one of the most abundant rodents on the island. However, its genetic background at the genomic level remains unclear, and clarifying this would help us to infer the timing of introduction and route of migration. In this study, we determined the whole-genome sequences of five Madagascar house mice captured from an inland location in Madagascar. We examined the genetic background of samples by analyzing the mitochondrial and autosomal genomes. We confirmed that the mitochondrial genome lineages of collected samples formed a single clade placed at one of the most basal positions in the Mus musculus species. Autosomal genomic sequences revealed that these samples are most closely related to the subspecies M. m. castaneus (CAS), but also contain a genetic component of the subspecies M. m. domesticus (DOM). The signature of a strong population bottleneck 1,000–3,000 years ago was observed in both mitochondrial and autosomal genomic data. In a comparison with global samples of M. musculus, the Madagascar samples showed strong genetic affinity to many CAS samples across a wide range of Indian Ocean coastal and insular regions, with divergence time estimated as around 4,000 years ago. These findings support the proposition that the ancestors of these animals started to colonize the island with human agricultural activity and experienced a complex history during their establishment.</p>
収録刊行物
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- Genes & Genetic Systems
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Genes & Genetic Systems 97 (4), 193-207, 2022-08-01
日本遺伝学会