Exosomal proteins in cancer: exosome-mediated metastasis and biomarker potential

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  • Hoshino Ayuko
    Department of Life Science and Technology, Tokyo Institute of Technology

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  • 腫瘍関連エクソソームのプロテオミクスから解析する転移機構と診断バイオマーカー

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<p>Exosomes, first thought to function only as cellular garbage disposal, are secreted by all cells and have recently been discovered that they also function as a cell-cell communication tool. We have previously shown that cancer cells send "exosomes" to the future site of metastasis to alter the environment to a favorable place where cancer cells can successfully metastasize. In this review, I will discuss how exosomes define the metastatic sites, potential for using plasma-derived exosomes to identify cancer, or even define a panel of tumor-type specific exosomal proteins, which may help classify tumors of unknown primary origin.</p>

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