Description of non-thermal sterilization system combining medium-pressure ultraviolet lamps and filtration sterilization
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- HAYAKAWA Atsushi
- Technical Development Department Aseptic Systems Co., Ltd.
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- WADA Yuiko
- Technical Development Department Aseptic Systems Co., Ltd.
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- YAMAMOTO Yukinori
- Technical Development Department Aseptic Systems Co., Ltd.
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- MURAKAMI Junichi
- Technical Development Department Aseptic Systems Co., Ltd.
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- INOUE Yoshitaka
- Technical Development Department Aseptic Systems Co., Ltd.
Bibliographic Information
- Other Title
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- 中圧紫外線ランプとろ過滅菌フィルターを組合せた非加熱滅菌システムの解説
Description
<p>Through this paper, we aimed to describe the new concept of reducing carbon dioxide (CO2) emissions from aseptic processing equipment as well as the concept and prospects of a non-thermal sterilization system (called GREEN ASEPTIC) combining medium-pressure (MP) ultraviolet lamps and filtration sterilization. Considering that filterable bacteria can pass through a sterile filter with a pore size of 0.2 μm, filtration sterilization has not been adopted in aseptic polyethylene terephthalate (PET) bottle filling systems for low-acid beverages. Therefore, we examined the ultraviolet (UV) sensitivity of twelve types of filterable bacteria and Bacillus atrophaeus spores via bench-scale collimated beam testing. The results showed that the UV resistance of the filterable microbes was about half or less that of B. atrophaeus spores. Additionally, the UV light emitted via MP lamps was more effective for the disinfection of these bacteria under our experimental conditions than low-pressure (LP) lamps. The sterilization effect on B. atrophaeus spores was also verified at 80 mJ/cm2 with Atlantium's MP lamps. The addition of 1×107 colony-forming units of B. atrophaeus spores to pure water at a flow rate of 18 m3/h killed all the spores, with a more than 7-log reduction value.</p><p>These results suggest that the combination of MP lamps and filtration sterilization can produce sterile liquids of the same quality as those produced by ultra-high- temperature (UHT) sterilizers and can be expected to significantly reduce CO2 emissions from aseptic processing equipment.</p>
Journal
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- PDA Journal of GMP and Validation in Japan
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PDA Journal of GMP and Validation in Japan 24 (2), 32-40, 2022
Parenteral Drug Association Japan Chapter
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Keywords
Details 詳細情報について
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- CRID
- 1390857512441403136
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- ISSN
- 18811728
- 13444891
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed