Simple drainage versus drainage with minocycline infusion for symptomatic hepatic cysts

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  • Kinoshita Satoshi
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center Gastroenterology, Saitama Medical Center
  • Nishizawa Toshihiro
    Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital
  • Tojo Masaya
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center
  • Hirai Yuichiro
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center Endoscopy Division, National Cancer Center Hospital
  • Nakazato Yoshihiro
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center Gastroenterology, Saitama Medical Center
  • Miyanaga Ryoichi
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center
  • Fujimoto Ai
    Department of Gastroenterology, National Hospital Organization Tokyo Medical Center Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Toho University
  • Inoue Kazuaki
    Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital
  • Ebinuma Hirotoshi
    Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital
  • Suzuki Hidekazu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine
  • Kikuchi Masahiro
    Gastroenterology, Clinic of a Wind, Komazawa

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<p>Percutaneous treatment of symptomatic hepatic cysts includes simple drainage and drainage with sclerosing agents. We compared the efficacy of simple drainage with that of drainage with minocycline infusion for treating symptomatic hepatic cysts. We retrospectively evaluated 11 patients who underwent percutaneous drainage of symptomatic hepatic cysts. In seven cases, minocycline infusion was added at the discretion of the clinician. Cyst volume was evaluated before drainage, immediately after drainage, and after long-term follow-up. Cyst volume was calculated before treatment by multiplying the orthogonal diameters using the ellipsoid formula. Relapse was defined as the regrowth of the cyst with symptoms. Cyst volume immediately after drainage and after long-term follow-up was significantly less than that before treatment for the drainage with minocycline infusion group (p<0.05) but not for the simple drainage group. The relapse rates were 25% (1/4) for the simple drainage group and 0% for the drainage with minocycline infusion group. Drainage with minocycline infusion could be a promising option for treating symptomatic hepatic cysts, although simple drainage was not reliable.</p>

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