Conventional and Kampo Medicine Treatment for Mild-to-moderate COVID-19: A Multicenter, Retrospective, Observational Study by the Integrative Management in Japan for Epidemic Disease (IMJEDI Study-observation)
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- Takayama Shin
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Yoshino Tetsuhiro
- Center for Kampo Medicine, Keio University School of Medicine, Japan
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- Koizumi Sayaka
- Department of Internal Medicine, Kamitsuga General Hospital, Japan
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- Irie Yasuhito
- Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Japan
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- Suzuki Tomoko
- Department of General Medicine, Saitama Medical University Hospital, Japan
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- Fujii Susumu
- Department of Cardiovascular Surgery, Ogikubo Hospital, Japan
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- Katori Rie
- Association of Medical Corporation Riseijinkai Katori Clinic, Japan
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- Kainuma Mosaburo
- Department of Japanese Oriental Medicine, Toyama University Hospital, Japan
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- Kobayashi Seiichi
- Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Japan
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- Nogami Tatsuya
- Department of Kampo Medicine, Tokai University, School of Medicine, Japan
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- Yokota Kenichi
- Department of Surgery, Department of Respiratory Medicine, Kesennuma City Hospital, Japan
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- Yamazaki Mayuko
- Department of Kampo and Nephrology, Saiseikai Kurihashi Hospital, Japan
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- Minakawa Satoko
- Department of Clinical Laboratory, Hirosaki University Hospital, Japan
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- Chiba Shigeki
- Department of Surgery, Department of Respiratory Medicine, Kesennuma City Hospital, Japan
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- Suda Norio
- Department of Internal Medicine and Kampo Medicine, Suda Medical Clinic, Japan
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- Nakada Yoshinobu
- Department of Internal Medicine, Shonan Hospital, Japan
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- Ishige Tatsuya
- Oriental Medicine Research Center, Kitasato University, Japan
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- Maehara Hirofumi
- Department of Otorhinolaryngology, Ekota Maehara Clinic, Japan
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- Tanaka Yutaka
- Department of Kampo Medicine, Hyogo Prefectural Amagasaki General Medical Center, Japan
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- Nagase Mahiko
- Kichijyoji Traditional Chinese Medicine Clinic, Japan
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- Kashio Akihiko
- Kyuden Family Clinic, Japan
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- Komatsu Kazuhisa
- Komatsu Surgery Internal Medicine Clinic, Japan
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- Nojiri Makoto
- Shirakawa Hospital, Japan
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- Shimooki Osamu
- Iwate Medical University Hospital, Iwate Medical University Uchimaru Medical Center, Japan
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- Nakamoto Kayo
- Japan Traditional Chinese Medical Foundation of Osaka, Japan
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- Arita Ryutaro
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Ono Rie
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Saito Natsumi
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Kikuchi Akiko
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Ohsawa Minoru
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Nakae Hajime
- Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Japan
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- Mitsuma Tadamichi
- Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Japan
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- Mimura Masaru
- Center for Kampo Medicine, Keio University School of Medicine, Japan Department of Neuropsychiatry, Keio University School of Medicine, Japan
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- Ishii Tadashi
- Department of Education and Support for Regional Medicine (General and Kampo Medicine), Tohoku University Hospital, Japan
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- Nochioka Kotaro
- Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan
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- Chiu Shih-Wei
- Division of Biostatistics, Tohoku University Graduate School of Medicine, Japan
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- Yamaguchi Takuhiro
- Division of Biostatistics, Tohoku University Graduate School of Medicine, Japan
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- Namiki Takao
- Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University, Japan
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- Hisanaga Akito
- Hospital Bando, Japan
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- Mitani Kazuo
- Medical Corporation Mitani Family Clinic, Japan
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- Ito Takashi
- Akashi Clinic Kanda, Japan
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説明
<p>Objective Patients in whom coronavirus disease 2019 (COVID-19) was suspected or confirmed between January 1, 2020, and October 31, 2021, were enrolled from Japanese hospitals in this multicenter, retrospective, observational study. </p><p>Methods Data on the treatment administered (including conventional and Kampo medicine) and changes in common cold-like symptoms (such as fever, cough, sputum, dyspnea, fatigue, and diarrhea) were collected from their medical records. The primary outcome was the number of days without a fever (with a body temperature <37°C). The secondary outcomes were symptomatic relief and the worsening of illness, defined as the presence of a condition requiring oxygen inhalation. The outcomes of patients treated with and without Kampo medicine were compared. </p><p>Patients We enrolled 962 patients, among whom 528 received conventional and Kampo treatment (Kampo group) and 434 received conventional treatment (non-Kampo group). </p><p>Results Overall, after adjusting for the staging of COVID-19 and risk factors, there were no significant between-group differences in the symptoms or number of days being afebrile. After performing propensity score matching and restricting the included cases to those with confirmed COVID-19 who did not receive steroid administration and initiated treatment within 4 days from the onset, the risk of illness worsening was significantly lower in the Kampo group than in the non-Kampo group (odds ratio=0.113, 95% confidence interval: 0.014-0.928, p=0.0424). </p><p>Conclusion Early Kampo treatment may suppress illness worsening risk in COVID-19 cases without steroid use. Further randomized controlled studies are needed to confirm the clinical benefit of Kampo medicine for COVID-19. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 62 (2), 187-199, 2023-01-15
一般社団法人 日本内科学会
