Capsaicin, TRPV1 ligand, suppresses inflammatory bone resorption
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- Sugasaki Moe
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technolog
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- Tominari Tsukasa
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technolog
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- Matsumoto Chiho
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technolog
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- Hirata Michiko
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technolog
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- Inada Masaki
- Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technolog
Bibliographic Information
- Other Title
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- TRPV1リガンド・カプサイシンによる炎症性骨破壊の抑制作用
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Abstract
<p>Capsaicin, a pungent component in capsicum, is a ligand for TRPV1 (transient receptor potential vanilloid 1)which regulates nerve-related pein-sensitive signal and inflammation. However, the effects of capsaicin on bone metabolism are not elucidated. We have showed that capsaicin inhibited LPS-induced osteoclast differentiation and bone resorbing activity. The receptor of capsaicin, TRPV1 was only expressed in osteoblasts but not in macrophages and osteoclast precursor cells. In osteoblasts, capsaicin suppressed PG (prostaglandin) E2 production through the downregulation of COX (cyclooxygenase)-2 and mPGES (membrane-bound PGE synthase)-1 expression, resulting in suppression of RANKL (receptor activator of NF-κB ligand) expression. In vivo study, intraperitoneally injection of LPS resulted in severe bone loss in the femur and treatment of capsaicin attenuated its bone loss. Current reports showed that capsaicin has a protective effect on periodontal bone resorption through a nerve system-mediated mechanism, and other report suggested capsaicin has abilities to direct inhibition of periodontal pathogens. Controversially, TRPV1 knockout mice have shown resistance to periodontal disease. In this review, we described the effects of capsaicin on inflammatory bone diseases. We suggest functional food capsaicin is one of a candidate for maintaining bone health.</p>
Journal
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- Functional Food Research
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Functional Food Research 18 (0), 22-27, 2022-09-12
Society for Functional Food Research
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Details 詳細情報について
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- CRID
- 1390857844453722496
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- ISSN
- 24343048
- 24323357
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- Text Lang
- ja
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- Data Source
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- JaLC
- KAKEN
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- Abstract License Flag
- Disallowed