オピオイド誘発性便秘症に対するナルデメジン予防投与の実態調査

DOI Web Site Web Site 参考文献19件
  • 小澤 有輝
    一般財団法人神奈川県警友会けいゆう病院薬剤部
  • 春木 弥生
    一般財団法人神奈川県警友会けいゆう病院薬剤部
  • 大畑 芽衣子
    一般財団法人神奈川県警友会けいゆう病院薬剤部
  • 磯野 永依
    一般財団法人神奈川県警友会けいゆう病院緩和ケア内科
  • 高橋 みなみ
    一般財団法人神奈川県警友会けいゆう病院緩和ケア内科
  • 楯 亜紀
    一般財団法人神奈川県警友会けいゆう病院麻酔科
  • 浮田 聖子
    一般財団法人神奈川県警友会けいゆう病院看護部
  • 林 誠一
    一般財団法人神奈川県警友会けいゆう病院薬剤部

書誌事項

タイトル別名
  • Survey of Prophylactic Administration of Naldemedine for Opioid-induced Constipation
  • オピオイド ユウハツセイ ベンピショウ ニ タイスル ナルデメジン ヨボウ トウヨ ノ ジッタイ チョウサ

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抄録

<p>Opioid-induced constipation (OIC), an adverse event that occurs due to opioid analgesics, reportedly causes poor quality of life and adherence to opioid analgesics in patients. Therefore, this issue must be addressed appropriately. Naldemedine (NAL), a peripherally-acting μ-opioid receptor antagonist, is currently recommended for treating OIC when other laxatives are ineffective, but there have been no clinical reports of NAL being used prophylactically for OIC. Therefore, we conducted a retrospective survey of hospitalized patients who received NAL as prophylaxis for OIC with strong opioid analgesics to clarify the reality of this situation and to consider points to be taken into account in its clinical implementation. In this study, 61.7% of the subjects had an Eastern Cooperative Oncology Group performance status score of 3 or higher. The rate of addition of new laxatives and increased laxatives during seven days of NAL prophylaxis was 46.8%, and the rate of diarrhea was 6.1%. This study suggests that patients initiated with strong opioid analgesics during hospitalization often presented with poor performance status, and it is important to pay attention to constipation even under NAL prophylaxis. However, the incidence of diarrhea was low, and the safety of NAL prophylaxis was considered to be good.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 143 (2), 183-189, 2023-02-01

    公益社団法人 日本薬学会

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