Elucidation of Physiological Functions of Vitamin K in the Brain and Development of New Derivatives for Neuroregeneration

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  • Hirota Yoshihisa
    Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology Pharmaceutical Sciences Research, Department of Systems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology

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Other Title
  • 脳内ビタミンKの生理機能の解明及び脳神経再生を志向した新規誘導体の創製
  • ノウナイ ビタミン K ノ セイリ キノウ ノ カイメイ オヨビ ノウ シンケイ サイセイ オ シコウ シタ シンキ ユウドウタイ ノ ソウセイ

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Abstract

<p>Vitamin K plays an important role in blood coagulation and bone formation. However, apart from the liver and bone, the role of vitamin K in other tissues remains unknown. Previously, we have reported on high concentrations of vitamin K in the mouse brain and investigated vitamin K conversion in brain tissue. This led us to hypothesised the possibility of vitamin K contributing significantly towards maintenance and function of the cranial nervous system. In this review, we summarise the synthesis of novel vitamin K derivatives, their neuronal differentiation inducing activities and the induction mechanism. The findings from this study will provide insights into the physiological roles of vitamin K in the brain.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 143 (3), 199-203, 2023-03-01

    The Pharmaceutical Society of Japan

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