Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure

DOI 機関リポジトリ (HANDLE) オープンアクセス
  • LI Lixia
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
  • DONG Kejun
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
  • CHEN Chen
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
  • CHEN Kun
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
  • SHI Yanhong
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
  • QIU Xuchun
    Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology
  • 島崎 洋平
    九州大学大学院農学研究院
  • 大嶋 雄治
    九州大学大学院農学研究院

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説明

Amitriptyline (AMI) is a tricyclic antidepressant (TCA) that has been widely used to treat depression. The widespread use has caused AMI to enter the environmental waters with a maximum concentration of μg/L. However, knowledge of its persistent toxic effects on fish is still limited. Therefore, this study exposed female zebrafish to 10 μg/L of AMI for seven days, followed by a 21–day recovery in AMI–free water. The results showed that AMI could induce persistent or delayed hypoactivity and abnormal social behavior in zebrafish. AMI exposure also significantly altered the brain levels of 5–HT, 5–HIAA, and ACH. Correlation analysis revealed that 5–HT and ACH were negatively correlated with locomotor activity, and 5–HT was also positively correlated with social interaction. Our finding demonstrated that AMI could cause persistent abnormal behavior in zebrafish and alter the brain neurotransmitter levels in zebrafish, suggesting that those long–term impact should not be ignored.

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